Glossary

CNS: Central Nervous System (brain, spinal cord)

Ca++: Calcium ions

NASH: (Non-Alcoholic SteatoHepatitis) Fatty inflammation of the liver in people who do not abuse alcohol. It is typically a chronic condition that causes no symptoms or very mild symptoms but can sometimes cause progressive scarring and cirrhosis of the liver.

Neuron: an electrically excitable brain cell that receives, processes, and transmits information through electrical and chemical signals.

Excitotoxicity: Death of neurons from being over-stimulated (over-excited). This occurs when neurons are injured by trauma or disease.

Blood-brain barrier: A layer of endothelial cells and brain cells that controls the entry of chemicals into the brain. Permitted chemicals are actively transported into the brain.

Blood-nerve barrier: A similar barrier to the blood-brain barrier that controls the entry of chemicals into peripheral nerves.

Peripheral nerves: Nerves that connect the central nervous system with the rest of the body.

Neurotransmitters: Chemicals that enable electrical signals to be passed between neurons.

Glutamate: The most common form of neurotransmitter in the brain.

Peripheral neuropathy: An inflammatory condition affecting peripheral nerves charecterised by pain and loss of function.

CIPN: Chemotherapy-Induced Peripheral Neuropathy

DPN: Diabetic Peripheral Neuropathy

LDL cholesterol: Low-density lipoprotein cholesterol, commonly referred to as 'bad' cholesterol. Elevated LDL levels are associated with an increased risk of heart disease. Lipoproteins, which are combinations of fats (lipids) and proteins, are the form in which lipids are transported in the blood.

PCSK9: The PCSK9 gene provides instructions for making a protein that helps regulate the amount of LDL cholesterol in the bloodstream.

UC: Ulcerative Colitis is a form of inflammatory bowel disease (IBD). It causes swelling, ulcerations, and potential loss of function of the large intestine.

Hypercholesterolaemia: an excess of cholesterol in the bloodstream.

LIPROSE: Lipid Protective Shield (owned by Noxopharm)

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