NYRADA INC (ASX:NYR) 18 Source: Parmar et. al. 2023 Translational Stroke Research Nyrada’s NYR-BI03 is specifically designed to block TRPC 3/6/7 channels which play crucial roles in calcium signalling and are involved in a wide range of physiological and pathological processes. Dr. Parmar also presented on Nyrada’s brain injury program at the US Military Health System Research Symposium in mid-August 2023. • TRPC3 channels play a role in various physiological functions, including vascular smooth muscle contraction, neuronal growth, and immune responses. • TRPC6 channels are essential for the regulation of vascular tone, kidney function, and various cellular processes. • TRPC7 are known to participate in calcium entry and signalling pathways. Preclinical Stroke Study During the financial year, Nyrada conducted a preclinical study to evaluate the efficacy of its lead Brain Injury Program candidate NYR-BI03 in preventing secondary brain injury following a stroke. The study reported a significant neuroprotective signal, providing strong evidence of potential efficacy. NYR-BI03 is a first-in-class therapy with a novel mechanism of action designed to selectively block TRPC ion channels, which are over-activated during brain trauma, causing calcium overload and brain cell death. Currently, there are no FDA-approved drugs for the treatment of secondary brain injury. In collaboration with UNSW Sydney, the study induced a focal ischemic stroke using a photothrombotic model in test animals. 16 test animals were treated with either NYR-BI03 or a vehicle 30 minutes post-injury, with treatment administered for 72 hours via continuous intravenous infusion. Magnetic Resonance Imaging (MRI) was used to quantify the resulting brain injury in both drug-treated and vehicle-treated animals, focusing on the penumbra region, which NYR-BI03 targets. MRI results showed a statistically significant neuroprotection (p-value 0.0213), with NYR-BI03 therapy rescuing an average of 42% of brain injury in the penumbra region. All animals survived the brain injury and treatment without any drug-related adverse effects.
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